Tetracyclines in malaria
نویسندگان
چکیده
منابع مشابه
The tetracyclines.
The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.
متن کاملTetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.
Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated their stage-specific activities, impacts on parasite transcription, and effects on two predicted organelle targets, the apicoplast and the mitochondrion, in cultured Plasmodium falciparum. Antimalarial effects were ...
متن کاملYeast Growth and Tetracyclines
COWLES, P. B. 1941 Germicidal action of hydrogen ion and of lower fatty acid. Yale J. Biol. Med., 13, 511-578. DOMIAGK, G. 1935 A new class of disinfectants. Deut. med. Woshschr., 61, 829-832. FRANK, H. G. AND REINER, L. 1954 The action of fat-acids on Trichomnonas vaginalis. J. Immunol., 72, 191-193. KEENEY, E. L. 1943 Fungistatic and fungicidal effect of sodium propionate on common pathogens....
متن کاملNeuroprotection by tetracyclines.
The neuroprotective properties of tetracyclines have been clearly established in rodent models of acute and chronic neurodegeneration during the past few years. Recent findings have provided novel insights into the molecular and cellular mechanisms of protection of neurons and oligodendrocytes by tetracyclines. These advances have prompted several clinical trials with minocycline, the most effe...
متن کاملTetracyclines and Neuromuscular Disorders
Tetracyclines are a class of antibiotics which could act as neuroprotective molecules in several neurological disorders, such as Huntington disease, Parkinson disease, stroke and multiple sclerosis. The main biological effects of tetracyclines are the inhibition of microglial activation, the attenuation of apoptosis and the suppression of reactive oxygen species production. The anti-apoptotic e...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2015
ISSN: 1475-2875
DOI: 10.1186/s12936-015-0980-0